Redefining Xenograft Biocompatibility
The New Era of Guided Bone Regeneration
For decades clinicians accepted the compromise: excellent volume stability from xenografts — but always with the risk of immunogenic response.
OptyBone ends that compromise using the world’s only patented EstRem™ Esterification Cell-Removal Technology — delivering completely antigen-free equine grafts with fully preserved collagen matrix and natural osteoconductive architecture.
EstRem™ Technology Patented · Proven · Revolutionary
No harsh enzymes. No destructive high heat. No loss of growth factors.
EstRem™ uses a selective esterification reaction to completely eliminate every immunogenic molecule while preserving the native extracellular matrix, Type-I collagen, BMPs, TGF-β and natural hydroxyapatite — creating the most biocompatible xenograft in clinical history.
Antigen Removal
Biocompatibility
Reported Reactions
One Technology Three Superior Products
OptyBone Matrix → Fully preserved ECM for natural remodeling
OptyBone Apatite → Pure slow-resorbing mineral for maximum volume stability
OptyBone DEM → Partially demineralized flexible graft with enhanced bioactivity
Whatever the clinical challenge — we have the perfect OptyBone solution.



Reduction in Antigenic Material
Organic Component Removal
Long-Term Volume Maintenance
Clinical Success Rate
